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Generation of composites from borides with tuneable electrical conductivities using peptides optimized by genetic engineering; characterization of the bio-solid interactions by modelling and AFM

An interaction of inorganic materials with peptides shall be created in a chemobiological composite of phages and boride particles. Binding properties are to be optimized by genetic engineering which will employ a screening system based on biopanning specific peptides with preferences for different borides with different physical properties. Two model systems are used: 1) for a start a metallic, magnetic boride in form of wet-chemically synthesized nanoparticles 2) later on a boron-rich ceramic which is very high-temperature stable and inert...
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Barbara Albert, Robert Berger, Robert Stark, Nico van der Vegt; Darmstadt
Bernhard Hauer; Stuttgart


Genetically optimized Tobacco mosaic viruses as scaffold for the in vitro generation of semiconductor bio/metal-oxide nanostructured architectures
The goal of this project is to establish a mild protein-based biomineralization process for the formation of defined layered semiconductors which can be employed for the production of electrical devices like field-effect transistors (FET) or sensors. To this aim, an in vitro assembly approach using different genetically modified Tobacco mosaic virus (TMV) coat proteins as protein LEGO® for the generation of surface-modified virus-like reactive rods and fibers as structure-directing 1D scaffold will be applied...
Joachim Bill, Sabine Eiben, Holger Jeske; Stuttgart
Jörg J. Schneider; Darmstadt


Genetically controlled self-assembly of inorganic-bioorganic hybrid structures: From sponge genes to layered materials.
Conventional processing techniques mostly exclude the preparation of multifunctional silica- and other metal(loid) oxide-based materials with an expanded property spectrum. Therefore, the potential of those bionic approaches is huge that apply the principles of gene-regulated biosilicification for the synthesis of such materials at ambient conditions. Enzymatic, gene-regulated silica metabolism is only known to exist in the animal phylum Porifera (sponges) and, hence, is very promising for the design of inorganic-bioorganic hybrids in the field of molecular bionics...
Wolfgang Tremel, Matthias P. Wiens; Mainz 
Fabrication of 2D magnetic nanostructures via a knowledge-based biomimetic approach supported by atomistic modeling
Lucio Colombi Ciacchi, Laura Treccani; Bremen   


Multifunctional Layered Magnetite Composites
Nature provides many archetypes of highly ordered systems, some of these biomaterials are known for their remarkable mechanical properties. One particularly interesting class are biominerals which are organic-inorganic hybrid materials and abundant in Nature. Nacre is one of these biominerals combining both stiffness and hardness. The hierarchical structuring of highly organized crystal platelet layers separated by thin layers of organic material is responsible for the fracture resistance of nacre...
Helmut Cölfen; Konstanz
Damien Faivre; Potsdam
Dietmar Schwahn; Jülich
Dirk Zahn; Erlangen 
Bio-inorganic hybrid membranes with nanoporosity control by genetically engineered viral seal rings
A novel preparation route is proposed to obtain bio/inorganic hybrid membranes with arrays of nanoscaled pores. The procedure allows controlling the distance between pores as well as their diameter. For that purpose, a virus template-assisted solid state membrane approach will be developed. Specifically, Tobacco mosaic virus (TMV) assembly intermediates forming protein disks of precise dimensions with an inner 4 nm pore and an outer diameter of 18 nm will be used...
Hartmut Gliemann; Karlsruhe
Christina Wege; Stuttgart
Paul Ziemann; Ulm
Diatom Nanobiotechnology: Genetic Engineering of Silicia Biomineralization for Syntheses of Multifunctional Nano- to Micropatterned Hybrid Materials
Diatoms are single-celled microorganisms with remarkable SiO2 (silica) forming capabilities. Diatom silica exhibits hierarchical patterns of nano- to mircoscale features, which endow the material with interesting properties that are difficult to reproduce synthetically. The project combines methods for the deposition of inorganic materials under mild reaction conditions with genetic manipulation of diatom silica biogenesis to synthesize hierarchically structured organic-inorganic hybrid materials with interesting optical, catalytic, and magnetic properties...
Nils Kröger; Dresden
Cordt Andreas Zollfrank; München


Tailoring cementitious materials with gentically, engineered microbial exopolysaccharides, a biologically inspired approach towards high-performance construction materials
Four microbial polysaccharides, namely welan gum, scleroglucan, diutan gum and EPS I, a modification of xanthan gum, were chosen for the fabrication of bio-nanocomposites based on layered double hydroxides. The intercalation abilities of welan gum and scleroglucan has been ascertained. The reaction products were synthesized via direct coprecipitation of Zn(NO3)2 and Al(NO3)3 in the polysaccharide solutions at pH ~ 8.5. Following this, they were characterized by powder X-ray diffraction (XRD), elemental and thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and scanning and transmission electron microscopy (SEM and TEM)...
Johann Plank, Garching
Volker Sieber, Straubing 


Fabrication of nanomagnetic hybrid materials by genetic engineering and functionalization of bacterial magnetosomes 
Dirk Schüler, Planegg